Rare Earth (RE) such as Y, La, Sc and Gd ions doped Ce:Lu2SiO5 (LSO) crystals, were grown by Czochralski method. The concentrations of these RE ions in LSO crystals were measured, and their segregation coefficients were calculated according to the concentrations. La3+ was found to be helpful to increase the segregation coefficients of Ce3+ in LSO crystals. Transmission, UV and X-ray excited emission spectra, and UV light emission decay curves of RE-doped LSO crystals were tested at room temperature. No significant difference in emission spectra and decay time can be identified among these RE-doped LSO crystals. Doping with La3+ may improve the energy resolution and photoelectron yield of LSO crystals.