This paper presents the principles governing the design and development of a mobile application, as well as various aspects regarding its integration into a more complex RFID_B2B (radio frequency identification - business to business) system. Extending the applicability of RFID_B2B systems represents the main goal of such applications, which are generally expected to handle large amount of data, to operate in stand-alone mode and to allow their easy integration into complex RFID_B2B systems. The paper proposes new solutions and ideas regarding the design and development of a secure and very fast method for the communication and synchronization between the B2B servers and a mobile application running on various mobile devices.