For real time service, not only the data rate, but also the packet delay should be guaranteed. In this paper, by exploiting the queue status information and channel status information, a novel framework of joint spatial-frequency scheduling for real time service in MIMO-OFDMA system is proposed, and some joint spatial-frequency scheduling algorithm is proposed based on modified largest weighted delay first (M-LWDF), quality guaranteed (QG) and packet loss ratio (PLR) priority function. Comparing the simulation results of MIMO 1times2 case, M-LWDF achieves best performance; QG and M-LWDF scheduler may support 20 video user with 500 kbps data rate in 10 MHz bandwidth, and the spectrum efficiency may approach 0.9 bps/Hz. while for MIMO 2times4 results, QG scheduler may achieve best performance comprehensively, and more than 50 video user can be supported in 10 MHz, and the spectrum efficiency may approach 2.5 bps/Hz.