The changes of medical environments such as the growth of a patient with a chronic disease and the elderly, and the advance of the IT technology require highly qualified medical service of new paradigm. For the reason, home health management service has been focused with much expectations and interests. Our proposed home health management system (H2MS) monitors and manages daily physiological status which is easily acquired from multiple-sensor based ubiquitous bio-signal sensor during sleeping, bathing, evacuating, and living at home. H2MS is largely consisted of four functional subsystems: multiple-sensor based ubiquitous bio-signal sensor, home health intermediary client (H2IC), home health center (H2C), and home health service provider (H2SP). Each subsystem carried out their own processes and collaborated on a work with each other. H2MS provides various home health services for the wellness, as well as the elderly, chronic patient's illness, or terminal illness. Also, it is available to suggest various services: an early warning service according to the change of health status, advice service for health improvement, and appointment service for medical treatment. Moreover, this early warning service makes promptly emergency repairs as soon as occurrence of physiologically abnormal symptom. Consequently, early warning reports reduce the frequent intervention of high costed service of medical professionals.