It is desired that the user of a multidisciplinary design optimization (MDO) framework is capable of efficiently integrating and managing the resources distributed over heterogeneous platforms. This paper proposes a modern Web services-based MDO framework that enables the synthesis of available disciplinary and cross-disciplinary resources for MDO via the Globus Toolkit. A Web, an open and dynamic environment, accentuates a need for the design of high-assurance MDO framework with high degree of reliability, safety, and security.