Visible Human Project (VHP) gains an increasingly concern all over the world since it was first initiated in the 90's due to the benefits it brings to medical research, education and training. With the precise visible human datasets, tailor-made applications can be developed for various purposes. In this paper, we propose a novel computing tool for annotating anatomical structures in virtual anatomy applications. Our automatic labeling algorithm can also be applied to other related applications, e.g. virtual acupuncture, which involves similar anatomic annotation requirements. A real-time interactive application which will automatically generate tissues labels was developed. The user can gain further description of a tissue by clicking on the corresponding label and also drag the labels to desired positions.