A novel cost-effective real-time gamma radiation monitoring system based on metal oxide thick films was designed and tested. The changes in capacitances of ZnO and SnO2 thick film capacitors with interdigitated electrodes were monitored in real time under the influence of gamma radiation using miniaturized, low power, bi-directional wireless communication system. The capacitive interface circuitry was based on a Delta-sigma (SigmaDelta) modulator using switched capacitor (SC) circuit architecture with integrated on-chip temperature sensor. At the base station side, an frequency shift keying (FSK) receiver/transmitter is connected to another MCU unit, which send the received data or received instructions from a PC through a graphical user interface GUI. Industrial, scientific and medical (ISM) band RF (433 MHz) was used to achieve half duplex communication between the two sides. All the modules of the mixed signal system are integrated in a printed circuit board (PCB) of size 22.46times20.168 mm. The overall system supply voltage is 2.7 V maximum. 137Cs source with an activity of 370 kBq was used. An increase in the values of capacitance with radiation was recorded for both films to a certain dose level, determined by the material of sensitive layer.