Combining the field condition with operation requirements in large-scale automated three-dimensional garage, a simulation system was developed by adopting configuration technique. Ant colony algorithm was utilized to assign berth address rationally. Configuration software was used for establishing simulation model and data dictionary. This simulation system mimicked the tasking process of three-dimensional garage. It also had the functions such as communication interface and database interface. Finally, it was tested and satisfactory results were obtained. When applied to the development and field training of relevant engineering project, this system can shorten project cycle effectively, lower costs and reduce impact in production and operation