We have studied about annealing effect on V-based Laves phase compound multifilamentary superconducting wire using the Rapidly Heating and Quenching (RHQ) process in order to improve superconducting property. We found that the reaction layer within 10 microns was formed between powder mixture filament and V matrix after the RHQ process. The transport Jc values of samples post-annealed at 600degC for 10 hours were increased remarkably compared with as-quenched samples, and then Hc2 value calculated by Kramer's formula was increased from 14 T to 16 T by additional annealing. In this paper, the post-annealing condition effect on both microstructure and Jc-B property of V-based Laves phase compound superconductor made through RHQ process was investigated