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Noncompliance with assigned therapies is ubiquitous in randomized clinical trials. Treatment effects may be corrected for noncompliance using Robins' structural nested models, but few examples have been published. The Herpetic Eye Disease Study randomized 703 ocular herpes patients to 365 days of acyclovir or placebo between 1992 and 1996, and achieved over 90% compliance in both arms. The hazard...
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