Neutron irradiation of 7–12% Cr ferritic/martensitic steels below 425–450°C produces microstructural defects and precipitation that cause an increase in yield stress. This irradiation hardening causes embrittlement, which is observed in a Charpy impact or fracture toughness test as an increase in the ductile-brittle transition temperature. Based on observations that show little change in strength in steels irradiated above 425–450°C, the general conclusion has been that no embrittlement occurs above these temperatures. In a recent study of F82H steel, significant embrittlement was observed after irradiation at 500°C, but no hardening occurred. This embrittlement is apparently due to irradiation-accelerated Laves-phase precipitation. Observations of the embrittlement of F82H in the absence of irradiation hardening have been examined and analyzed with thermal-aging studies and computational thermodynamics calculations to illuminate and understand the embrittlement during irradiation.