With the widespread adoption of periodontal plastic surgery, trials comparing different types of root coverage therapy are increasingly being conducted. The coronally advanced flap (CAF) procedure is a very common approach for root coverage. This procedure is based on the coronal shift of the soft-tissues on the exposed root surface. A recent innovation in dentistry is the preparation and use of platelet-rich plasma (PRP), a concentrated suspension of growth factors, found in platelets. These growth factors are involved in wound healing and postulated as promoters of tissue regeneration. The purpose of this case report was to evaluate the clinical efficacy of a CAF used in combination with PRP, and to compare it with CAF alone, in the treatment of gingival recession.