To investigate the surgical findings and outcomes after vitrectomy for a lamellar macular hole (LMH).Retrospective, consecutive, interventional case series.Twenty-seven patients (27 eyes) with a lamellar macular hole and central vision loss.All patients underwent 3-port vitrectomy with internal limiting membrane (ILM) stripping by one of the authors. Best-corrected visual acuity (BCVA) and appearance by optical coherence tomography (OCT) were obtained preoperatively and postoperatively.Preoperative and postoperative BCVA and OCT imaging.Visual acuity improved postoperatively in 25 of 27 eyes (93%), with a mean improvement of 3.2 Snellen lines. Preoperative and postoperative OCT images were obtained in 24 of 27 eyes (89%) and were judged to have improved or normalized in 22 of 24 (92%) of these patients.In patients with central visual loss from a lamellar macular hole, vitrectomy with ILM stripping appears to be a beneficial treatment.