A corrosion-resistant Nb 0.05 Ti 0.95 O 2 material with high surface area was prepared by a sol–gel process. IrO 2 nanoparticles (about 16–33 wt%) were successfully loaded on Nb 0.05 Ti 0.95 O 2 powders as the electrocatalyst for oxygen evolution reaction (OER) in acidic medium. The IrO 2 /Nb 0.05 Ti 0.95 O 2 catalyst with the IrO 2 loading of 26 wt% exhibits the best mass normalized cyclic voltammetry charge and mass normalized activity among all the IrO 2 /Nb 0.05 Ti 0.95 O 2 catalysts because IrO 2 nanoparticles were uniformly supported on the surface of Nb 0.05 Ti 0.95 O 2 providing conductive channels to reduce the grain boundary resistance. Due to the anchoring effect of carrier on the catalyst, the stability of the supported IrO 2 was significantly improved as compared to the unsupported one. The IrO 2 /Nb 0.05 Ti 0.95 O 2 catalyst with 26 wt% IrO 2 loading demonstrates the best effectiveness of the OER activity and cost.