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− (±)-5-Me-8-OH-DPAT 4 was synthesized by a new synthetic pathway recently described by us. The (+)- and (−)-enantiomers 4 were prepared from the primary amine 8 by crystallisation of the (+)- and (−)-mandelic acid salts. The enantiomers reacted with propyl iodide and were demethylated by 48% HBr to the (+)- and (−)-4 compounds. These compounds had good affinity for 5-HT 1A receptors (K ...
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