In this study, irradiation-induced amorphization in silicon carbide (SiC) by 1MeV neutrons was investigated using molecular dynamics (MD) simulations. The crystalline-to-amorphous (c–a) transition occurred at 0.27dpa with a structure relaxation of the whole lattice. Fast neutrons have produced many displacement spikes with unsaturated coordinated atoms at the center. Our results have shown that the two-coordinated Si atoms play a key role in defect accumulation and amorphization. There are two types of such defects: displaced-atom-induced (D-type) defect and vacancy-induced (V-type) defect. The D-type defect tends to form clusters and promotes the formation of C Frenkel pairs after 0.13dpa. The V-type defect enhances the driving force of c–a transition and finally triggers amorphization at high concentration based on thermodynamics.