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Efficient palladium catalysts for the amination of aryl chlorides: a comparative study on the use of phosphium salts as precursors to bulky, electron-rich phosphines
Alkyl-di-(1-adamantyl)phosphonium salts are practical ligand precursors for the palladium-catalyzed amination of aryl chlorides. In the presence of typically 0.5mol% Pd(OAc) 2 and 1mol% of ligand precursor a variety of activated and deactivated aryl chlorides can be aminated in good to excellent yield (73–99%). Applying optimized conditions catalyst turnover numbers up to 10,000 have been achieved.