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This study demonstrates the feasibility of performing retrospective grading of breast cancer histology slides derived from multiple institutions. This has significant implications for conducting large multicentre trials where comparison of new prognostic markers with established prognostic indicators is required.
Vimentin and proliferating cell nuclear antigen (PCNA) immunohistochemical staining was performed in a series of 92 node-negative breast carcinomas and expression compared with tumour size, histological grade, nuclear grade, necrosis, lymphocytic infiltrate, oestrogen and progesterone receptors, and relapse rate.Vimentin was expressed in 13% of tumours and all positive cases were invasive ductal carcinomas...
Mondor's disease or thrombophlebitis of the subcutaneous veins of the chest region is a rare condition, with unknown etiology in most cases. Its association with breast cancer has been reported and in large series occurs in up to 10% of such patients. A literature review suggests that Mondor's disease in women with no obvious underlying cause should be investigated by mammography and careful clinical...
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