One of the key challenges for the design of sustainable chemical processes is to incorporate such concepts in the early phases of process design. In recent years, a few frameworks have been published to this direction, focusing mainly on continuous processes. However, the wide use of batch processes for the production of “low volume high value” chemicals makes the extension of such frameworks to this production environment indispensable. In the present study a recently presented multi-stage framework for multi-objective continuous process assessment is modified to incorporate batch process design aspects (e.g., cycle times, equipment utilization) in the form of early design phase indicators. Accordingly, a Productivity Loss Index (PLI) is defined for estimating periodic costs and environmental impacts, economic and environmental indicators are adjusted and a procedure to generate a base case separation process flowsheet is implemented. The modified framework is demonstrated on the design of a production process for 4-(2-methoxyethyl)-phenol considering seven potential synthesis routes.