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To delineate possibly distinct cognitive impairment in patients with multiple system atrophy (MSA) of cerebellar (MSA-C) and striatonigral (MSA-P) predominance, we employed two experimental tasks sensitive to striatal lesions: the Weather-Prediction Task (WPT) and the Object Alternation Task (OAT). Only MSA-P (n=10) patients showed reduced learning in the WPT and were impaired at maintaining the alternation...
In Huntington’s disease, frontostriatal dysfunction may impact cognitive and emotional processes critical for decision making. We investigated whether patients exhibit impairments in moral judgment and economic decision making, and if deficits were related to executive dysfunction or behavioral problems.Sixteen patients with Huntington’s disease and 16 controls judged the severity of items on a list...
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