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The effect of lanthanum ion (La 3+ ) on osteoblast function and cytoskeleton is assessed in vitro. Osteoblasts were isolated from Sprague–Dawley fetal neonatal rats. Cell proliferation and gene expression levels of cbfa-1, alkaline phosphatase (ALP), osteocalcin (OC), bone sialoprotein (BSP) and osteopontin (OPN) were examined by cell counting and RT-PCR. Cytoskeleton F-actin was stained with...
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