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Propanidid is a short acting anaesthetic with poor solubility in water. It was formerly marketed for clinical use as an intravenous (i.v.) anaesthetic in Cremophor EL (Epontol , propanidid 50 mg ml -1 ) but this was withdrawn due to anaphylactoid reactions to the vehicle. This paper reports on an aqueous formulation using hydroxypropyl-β-cyclodextrin (HP-β-CD) as a solubiliser. ...
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