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Five complexes were prepared with β-cyclodextrin and the insoluble, non-steroidal, anti-inflammatory drug indomethacin. The complexes were found to contain drug, water and ammonia in several unique combinations. It was theorized the complexes were tri-molecular in nature and their formation was controlled by a hydrophobic/hydrophilic balance created within the β-cyclodextrin ring cavity prior to complex...
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