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We have been evaluating the influence of different drying methods and of ionic crosslinkers on adhesive strength, cohesiveness as well as release behaviour of bioadhesive polymers. Chitosan-EDTA and carbomer were ionically crosslinked via 1,8-diaminooctane or l-lysine. The resulting polymers were either lyophilised or precipitated in acetone and air-dried. Tablets made of these pre-treated polymers...
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