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Evasion of the checks and balances that govern the human cell division cycle lies at the heart of all proliferative diseases. Because of the astonishing variety of ways that cancer cells manage to achieve growth advantages over normally proliferating cells, it can be expected that pharmacological reinstatement of cell cycle progression control should also be achievable in a multitude of ways. Very...
Patent Update is a regular column dedicated to the complex issues that affect patents in the genomics and proteomics field. In each issue, there are two sections compiled by patent attorneys. The first section, Patents – a Practical Perspective, is a commentary on current issues, landmark patents, useful patent resources and how to search them, and legislative changes that impact the pharma and biotech...
The process of deriving accurate annotations for genes in newly sequenced genomes has up to now been based largely on projection of results in one organism to genes in other organisms based on sequence similarity. We are now entering a period in which metabolic reconstructions will play an increasingly significant role. These reconstructions will support a gradual refinement of estimates of function,...
Arrays of antibodies and of other types of ligand-binding molecule (e.g. protein scaffolds or aptamers) provide a means for rapid detection of proteins and other analytes in multiple samples and ultimately for screening the human proteome in health and disease. The chief reasons for using an array-based approach to diagnostics and proteomics relate to the advantages associated with parallelisation,...
The most effective targeted cancer therapies have arisen from research into genetically altered oncogenes, including BCR-ABL, HER2, RAS and EGFR. Recent advances in cancer genetics have identified many regions of the genome that undergo amplification (increase in copy number) but, in most cases, the key oncogenic targets driving the growth and survival of cancer cells remain unknown. In this review,...
The comprehensive molecular approaches of cancer genomics provide unprecedented opportunity for the discovery of potential new targets. Through the establishment of a suite of research programs, focused towards the generation of technological and informational resources for the research community, the National Cancer Institute seeks to nurture the interface of cancer and genomics. The components of...
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