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Vernonia colorata is used throughout Africa to treat various ailments. Its antiplasmodial activity has been widely reported. Using bioassay-guided fractionation, we isolated two antiplasmodial compounds — vernolide (IC 50 =1.87 μg/ml) and vernodalin (IC 50 =0.52 μg/ml) with selective indices of 1.02 and 2.79 for vernolide and vernodalin respectively. These compounds are non-specific...
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