Vortex flow reactors (VFRs) are a good option when fragile particles are present in the medium, due to their gentle but efficient stirring characteristics. However, the presence of a by-pass stream may deteriorate the reactor performance, and particles of inadequate density may either settle down or clog the reactor outlet. This work assessed the performance of an enzymic VFR. Fructose-glucose isomerization, catalyzed by immobilized glucoisomerase was the test reaction, taking advantage of the negligible changes that it causes on the medium viscosity. Intra- and extra-particle mass transfer effects were avoided. Reactor geometry (radius ratio η=0.677 and aspect ratio Γ=18.30) and residence time were selected aiming at possible applications of the device as a bioreaction and/or adsorption system. Visualization experiments confirmed that the vortices' cores stop their axial displacement when the rotation of the inner cylinder is increased. Intermediate rotations were the most detrimental to reactor performance, due to by-pass effects. Vortex agitation is very gentle, causing no detectable damage to shear-sensitive particles.