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The fate of exogenous radiolabeled growth hormone ( 125 I-hGH) was studied in Ames dwarf mice, which do not express growth hormone (GH) or prolactin (PRL) genes. Labeled GH was injected in low amounts that did not exceed the normal physiological GH concentration in mice. Binding of most of the injected 125 I-hGH by the GH-binding proteins (GHBPs) present in plasma represents the first...
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