From the rhizomes of Hemsleya panacis-scandens, four new cucurbitane glycosides and a known glycoside, perseapicroside A, were isolated. The structures of these new glycosides, named scandenosides R8-R11, were determined as the 3-O-β-d-glucopyranoside-26-O-β-d-glucopyranoside of 3β,26-dihydroxycucurbit-5-en-11- one, the 2-O-β-d-glucopyranoside of 2β,3α,16α-trihydroxy-22,23,24,25,26,27-hexanorcucurbit-5-ene-11,20-dione, the 3-O-β-d-glucopyranoside of 2β,3α,20(S),26,27-pentahydroxy-16α,23(S)-epoxycucurbita-5,24-dien-11-one and the 3-O-β-d-glucopyranoside-26-O-β-gentiobioside of 3β,11α,26-trihydroxy-5β,6β-epoxycucurbit-24-ene by spectroscopic and chemical methods. The structure of perseapicroside A was shown to be incorrect.