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Most late model high-resolution mass spectrometers (HRMS) are capable of performing sensitive and reliable quantifications of a large variety of analytes in global HR-full scan (HR-FS) or, if needed, in a more targeted SIM or MS2 mode. Usual LC-HRMS analysis records HR-FS that gives a global picture of a sample extract as virtually all ionized compounds are detected. This is more and more seen as...
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