The potential efficacy of the turmeric antioxidant protein (TAP) isolated from aqueous extract of turmeric (Curcuma Ionga) in protecting tissues from peroxidative damage was studied in the carbon tetrachloride treated rats. The increased basal as well as promoter induced lipid peroxide formation in the tissues of CCI 4 treated rats was significantly inhibited by 40-70% by TAP administration. The observed decreased antioxidant enzyme activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST) and antioxidant concentrations of reduced glutathione (GSH), total (TSH), protein (PSH) and non-protein (NPSH) thiols and ascorbic acid in the liver of CCI 4 treated rats were nearly normalized on TAP pretreatment. The increased activities registered with glucose-6-phosphate dehydrogenase (G6PD), lactate dehydrogenase (LDH), alanine transaminase (ALT) and aspartate transminase (AST) in the liver of CCI 4 treated rats were confered protection by 50-80% on TAP treatment. Glucose-6-phosphatase (G6Pase) and the membrane bound ATPase activities were decreased in CCI 4 treated animals and were completely restored on TAP treatment, thus, suggesting that TAP treatment prevents tissue injury by neutralizing the oxidative stress induced changes.