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Deregulated cell cycle progression is a hallmark of cancer. Accordingly, a major part of therapeutic drugs has been designed to inhibit cell proliferation and tumor growth. Metabolic imaging with positron emission tomography (PET) and the glucose analog 2′-[ 18 F]fluoro-2′-deoxyglucose (FDG) has been demonstrated to sensitively detect malignant tumors and to identify responding tumors early...
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