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The effects of friction between the powder and the mandrel on densification behavior of metal powder were investigated under cold isostatic pressing. The friction coefficients between the powder and the mandrels with different surface roughness were determined from the relationship between the compaction pressure and the ejection pressure of the mandrel from powder compacts. The elastoplastic constitutive equations based on the yield function of Shima and Oyane were implemented into a finite element program (ABAQUS) to simulate compaction responses of metal powders during cold isostatic pressing. Finite element results were compared with experimental data for pure iron powder under cold isostatic pressing.