Two new open-framework germanates, [Cd 2 (C 2 N 2 H 8 ) 3 ][Ge 9 O 18 (OH) 4 ] (1) and (C 8 N 4 H 26 )[Ge 9 O 18 (OH) 4 ] (2), have been hydrothermally synthesized and characterized by single-crystal X-ray diffraction. Compound 1 crystallizes in the orthorhombic space group, Pbca, with a=14.318(3), b=13.106(3), c=14.580(3) Å, V=2736.0(9) Å 3 , Z=4. The compound is the first organically templated cadmium germanate. The structure of 1 is constructed from two distinct motifs, a body-centered [Ge 9 O 18 (OH) 4 ] cluster and a cadmium complex [Cd 2 (C 2 N 2 H 8 ) 3 O 6 ], which integrate to generate a 3D architecture with neutral framework. The structures of 2 is closely related to that of 1 and has identical Ge 9 O 18 (OH) 4 clusters. It crystallizes in the orthorhombic space group, Pbca, with a=14.158(3), b=13.213(3), c=14.553(3) Å, V=2722.5(9) Å 3 , Z=4. The connectivity between the Ge 9 clusters result in a 3D open-framework structure. The quadruply protonated N,N′-bis(3-aminopropyl)ethylene diamine molecules are located in the free voids and interact with the macroanionic inorganic framework by extensive hydrogen bonds.