The mechanism and dynamic properties for the multi-channel reactions of CH 3 OCF 2 CHFCl+OH (R1), CH 2 FOCF 2 CHFCl+OH (R2), and CHF 2 OCF 2 CHFCl+OH (R3) were carried out theoretically. The geometric parameters were optimized at the BMK/6-311+G(d,p) level. Subsequently, the energies were refined at the BMC-CCSD level. Based on the information of partial potential energy surface, the rate constants were evaluated by using the canonical variational transition state theory (CVT) with a small-curvature tunneling correction (SCT) method. For every reaction, there are two possible H-abstraction positions, i.e., CH 3−n F n (n=0, 1, and 2) group and CHFCl group. The major reaction channel and the effect of fluorine substitution on the reactivity are explored. Both questions are elucidated by analyzing the reaction energy, barrier height, bond dissociation energy, and rate constants.