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To examine the role of N-methyl-d-aspartate receptors in the synaptic input-induced increase in Ca 2+ in layer II/III neurons of visual cortex, Ca 2+ imaging with a relatively low-affinity indicator was carried out simultaneously with whole-cell recordings of synaptic activity in cortical slices of young rats. Electrical stimulation of layer IV elicited excitatory postsynaptic potentials...
Embryonic nigral grafts can survive, reinnervate the striatum and reverse functional deficits in both experimental and clinical Parkinsonism. A major drawback is that only around 10% of the implanted dopaminergic neurons survive. 4,16,17,22,31 The underlying mechanisms leading to this 90% cell death are not fully understood, but oxidative...
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