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We have investigated the distribution of α 2C -adrenergic receptors in the rat striatum and characterized the striatal neuron types expressing these receptors. Sequential double-labelled immunocytochemistry was performed with a polyclonal antibody against rat α 2C -adrenoceptors and antibodies against GABA, Calbindin-D 28k , parvalbumin and calretinin. The...
Behavioral studies on gene-manipulated mice have started to elucidate the neurobiological functions of the α 2C -adrenoceptor (AR) subtype. In this study, we applied quantitative receptor autoradiography to investigate the potential anatomical correlates of the observed functional effects of altered α 2C -AR expression. Labeling of brain and spinal cord sections with the...
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