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The nucleus basalis of male Charles River Wistar rats was injected with 10 μg of the β-amyloid peptides β-(1–40) and β-(25–35) and changes in the morphology of the lesioned area, the release of acetylcholine from the cortex, and in behavior were investigated. Injections of saline and a scrambled (25–35) peptide were used as controls. One week after lesioning, a Congo Red-positive deposit of aggregated...
Alzheimer's disease is characterized by amyloid peptide formation and deposition, neurofibrillary tangles, central cholinergic dysfunction, and dementia; however, the relationship between these parameters is not well understood. We studied the effect of amyloid peptide formation and deposition on central cholinergic function in knock-in mice carrying the human amyloid precursor protein (APP) gene...
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