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To test the hypothesis that the human immunodeficiency virus-1-derived Tat protein may cause neuronal damage in the CNS, we evaluated the neurotoxicity of recombinant human immunodeficiency virus-1-derived Tat in vivo in seven-day-old rats. The intrinsic neurotoxicity of Tat (250 ng-1 μg) and the effects of direct intra-hippocampal co-infusion of Tat with N-methyl-d-aspartate were assessed. Extent...
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