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Hippocampal slices prepared from neonatal rats were cultured for several weeks, and excitotoxicity induced in CA1 pyramidal neurons byN-methyl-d-aspartate was evaluated at different culture stages. CA1 neurons cultured for one week exhibited cell death predominantly within 1–3 h after a 15-minN-methyl-d-aspartate insult (early death), whereas those cultured for three weeks showed cell death mainly...
Fimbria-fornix transection produces neuronal injury in the septum. This cellular pathology is characterized by somatodendritic vacuolar abnormalities in neurons. Because these cellular changes are reminiscent of some of the morphological abnormalities seen with glutamate receptor-mediated excitoxicity, we tested whether excitotoxic injury to the septal complex of adult rats mimics the degeneration...
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