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An increase of dynorphin levels is commonly observed in the substantia nigra of 6-hydroxy-dopamine-lesioned rats chronically treated with daily injections ofl-DOPA. This study investigates the potential of fetal mesencephalic grafts to restore normal levels of dynorphin in such cases. After 19 consecutive days of treatment withl-DOPA, lesioned rats with the most severe nigral cell loss showed increased...
Striatal expression of preproenkephalin and preprotachykinin messenger RNA was studied in normal controls and in patients with Parkinson's disease using in situ hybridization histochemistry. In controls, preproenkaphalin messenger RNA was expressed in a population of medium-sized neurons of mean cross-sectional area 165 μm 2 , accounting for 66% of striatal medium-sized neurons, whereas preprotachykinin...
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