The extent of data uncertainty of surface-wave measurements may have significant consequences on 1D seismic response analysis and it may lead to inaccurate estimate of design ground motion. In this paper, an attempt has been made to quantify the data measurement uncertainty from a large repetition of the field data at two test sites and to determine bounds of data uncertainty. In the inversion with neighborhood algorithm, we generated profiles below the misfit value calculated from the uncertainty bound. Equivalent profiles have been selected covering the whole misfit value range and these profiles are subjected to equivalent linear 1D ground response analysis. The results of seismic response analysis are presented in the form of amplification spectra and response spectra which show remarkable variations. Significant variation is observed in peak frequency and peak amplification and it differs from one site to the other based on their measured data uncertainty bound. Peak Ground Acceleration (PGA) and peak spectral acceleration at both the sites reflect very high Coefficient of Variation (COV).