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Amnestic mild cognitive impairment (aMCI) individuals are known to be at risk for progression to clinically probable Alzheimer’s disease (AD). The objective of this work is to measure the accuracy of an automated classification technique based on clinical-quality, single time-point structural magnetic resonance imaging (MRI) scans for the retrospective prediction of future clinical status in aMCI...
The therapeutic use of statins in reducing cholesterol requires careful assessment of potential neuroprotective and/or neurotoxic mechanisms. Chronic treatment with mevastatin (MV) exerts effects on cortical neuron morphology, protein expression and synaptic function in primary culture. MV impaired expression of synaptic proteins, reduced N-methyl-d-aspartate receptor (NMDAR) currents and accelerated...
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