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We have engineered transgenic Caenorhabditis elegans animals to inducibly express the human beta amyloid peptide (Aβ). Gene expression changes resulting from Aβ induction have been monitored by cDNA hybridization to glass slide microarrays containing probes for almost all known or predicted C. elegans genes. Using statistical criteria, we have identified 67 up-regulated and 240 down-regulated genes...
We evaluated pathomechanisms and systemic manifestations of Alzheimer disease (AD), an aging-related dementing neurodegenerative disorder, by expression profiling. Blood mononuclear cell (BMC) transcriptomes of sporadic AD subjects and aged-matched normal elderly controls (NEC) were compared using the human NIA microarray.Relative to the NEC samples, the Alzheimer BMC exhibited a significant decline...
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