Obesity provokes chronic low grade inflammation which contributes to the development of insulin resistance which ends up in Diabetes Mellitus, atherosclerosis, hyperlipidemias, polycystic ovary syndrome etc. In addition to their metabolic problems, obese individuals experience a progressive decline of their cognitive faculties. This decline may be a consequence of their metabolic disturbances, i.e. due to insulin resistance, diabetes-associate hyper- and hypoglycemias, atherogenesis of their vascular endothelium, hyperlipidemias, hypertension, etc. or due to a direct effect of obesity-provoked chronic low grade inflammation. On the other hand, a decline of cognition leads to poor life style choices which accelerate weight gain in a self-accelerating cycle. This review examines the role of obesity-induced chronic inflammation on aspects of cognitive faculties.
Current Opinion in Behavioral Sciences 2016, 9:169–175
This review comes from a themed issue on Diet, behavior and brain function
Edited by Dana M Small and Susanne E la Fleur
For a complete overview see the Issue and the Editorial
Available online 17th May 2016
http://dx.doi.org/10.1016/j.cobeha.2016.05.004
2352-1546/Published by Elsevier Ltd.