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The contribution of central PGE 2 levels to the nociceptive response in rats was assessed and the effects of the selective cPLA 2 α inhibitor efipladib, and pain therapies of different classes on these responses was determined. An inflammatory pain model was optimized in rats so that PGE 2 levels in the cerebrospinal fluid (CSF) could be directly correlated to the nociceptive...
We have demonstrated that the activation of P2X3 receptor on peripheral afferent neurons is critical to development of inflammatory hyperalgesia in peripheral tissue, although pharmacological administration of prostaglandin E 2 or sympathomimetic amines is enough to sensitize primary afferent neurons by acting directly in neuronal receptors. Therefore, to clarify this ambiguity this study...
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