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ABSTRACT: This report assesses the degree of iron overload in a cohort of patients in relationship to the presence or absence of the recently described 845 G→A (C282Y) and 187 C→G (H63D) mutations in the HFE (HLA-H) gene. Sixty-one patients with hereditary hemochromatosis diagnosed either with liver biopsy or on clinical grounds were included in this analysis. Forty-one patients were homozygous for...
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