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Adult rats with genetic absence epilepsy (GAERS) were shown to be hyperresponsive to convulsions induced by picrotoxin compared to nonepileptic controls (NERs). In contrast, young GAERS aged 22-26 days were less responsive than NERs to picrotoxin-induced convulsions. Around 30 days of age, when spontaneous spike-wave discharges develop in GAERS, the sensitivity of both strains did no longer differ...
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