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Redox-mediated upregulation of transcription of hepatocyte inducible nitric oxide synthase (iNOS) requires hepatocyte nuclear factor IV-alpha (HNF-4α). In this setting, PC4 is often isolated with HNF-4α in DNA-protein pull-down studies. Transcriptional coactivator PC4 facilitates activator-dependent transcription via interactions with basal transcriptional machinery that are independent of PC4-DNA...
Although flutamide (FTM), an androgen-receptor antagonist, normalizes the depressed immune and cardiac function in males after trauma hemorrhage (T-H), the mechanism responsible for its salutary effects remains unknown. We hypothesized that the salutary effects of FTM are mediated via upregulation of estrogen receptors (ERs).Male Sprague-Dawley rats underwent T-H (laparotomy and 90 minutes of hemorrhage...
Despite the emphasis on medical error as a major cause of hospital morbidity and mortality, there has been little published work on errors committed by trainees. This issue is particularly relevant to the training of surgeons and was addressed by our study.Sixty simulated laparoscopic cholecystectomies performed on restructured pig tissue models by 60 surgical trainees provided the study material...
Surgical treatment of necrotizing pancreatitis (NP) has undergone considerable changes during the past 2 decades. In this study, we report our experience of necrosectomy and continuous closed lavage over the past 19 years in an attempt to define changes in patient characteristics and outcome at an academic referral center.Among 1520 patients admitted with acute pancreatitis, 392 had NP, 285 of whom...
Endoscopic thoracic sympathectomy has been considered an effective treatment for palmar hyperhidrosis. However, the extent of resection has not been determined in terms of efficacy and complications. We compared the efficacy and complications of 2-ganglion and single-ganglion resection in patients with palmar hyperhidrosis.From 1995 to 2000, 75 patients underwent resection of thoracic ganglion T2...
Although sentinel lymph node (SLN) biopsy is widely accepted as a minimally invasive method of nodal staging, failure to identify an SLN mandates a level I/II axillary node dissection. The purpose of this study was to elucidate factors that independently predict failure to identify an SLN.Using a large multicenter prospective study of SLN biopsy for patients with invasive breast cancer, we performed...
Our aim was to investigate the development of intrahepatic venous anastomoses between the middle hepatic vein (MHV) and the right hepatic vein (RHV) in adult-to-adult, living donor, liver transplantation.Using Doppler ultrasonography, we studied the formation of venous anastomoses between the MHV tributaries for segments 5 and 8 (V5, V8) and the RHV in the liver remnants of 7 donors of a left liver,...
Tumor necrosis factor–related, apoptosis-inducing ligand (TRAIL) is a potent inducer of apoptosis in a wide variety of tumor cells, but it does not cause toxicity in the majority of normal cells. Therefore, TRAIL could become a suitable agent for anticancer therapies. However, a number of tumor cell lines are known to be resistant to TRAIL-induced apoptosis. The purpose of this study was to determine...
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