Therapeutic potential of morin, a member of flavonoid family, against carbon tetrachloride (CCl 4 )-induced liver fibrosis in rats was investigated and compared with that of silymarin. Results show that treatment with morin (30mg/kg/day) revealed attenuation in liver index and serum biomarkers of liver function that were enhanced by chronic CCl 4 intoxication. Further, morin inhibited the elevated levels of malondialdehyde and nitric oxide and restored hepatic reduced glutathione to its normal level. The increased production of hepatic hydroxyproline content by CCl 4 was markedly decreased by administration of morin. In addition, treatment with morin significantly attenuated the inflammatory responses caused by CCl 4 as evident by the decreased hepatic tumor necrosis factor-alpha (TNF-α) level, immunohistochemical expressions of inducible nitric oxide synthase and nuclear factor kappa B. Collectively, this study indicates that morin possesses antifibrotic effect in the CCl 4 model of fibrosis via reducing oxidative stress, inflammatory responses and fibrogenic markers.